無極4註冊_歐盟評估乙氧喹作為所有動物飼料添加

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無極4註冊_歐盟評估乙氧喹作為所有動物飼料添加

    食品夥伴網訊  2022年3月3日,據歐盟食品安全局(EFSA)消息,應歐盟委員會要求,歐盟動物飼料添加劑和產品(FEEDAP)研究小組就乙氧喹(ethoxyquin)作為所有動物飼料添加劑的安全性和有效性發表科學意見。

 
  部分原文報道如下:
 
  Ethoxyquin is synthetised from p-phenetidine, a possible mutagen, which remains in the additive as an impurity at co ncentrations of < 2.5 mg/kg additive. Ethoxyquin is co nsidered safe for all animal species at the proposed inclusion level of 50 mg/kg complete feed. However, owing the presence of p-phenetidine, no safe level of the additive in feed for long-living and reproductive animals could be identified. The FEEDAP Panel derived a health-ba sed guidance value of 0.006 mg ethoxyquin dimer (EQDM)/kg bw per day and applied it to the sum of ethoxyquin and its transformation products. A maximum total co ncentration of 50 mg ethoxyquin/kg complete feed for all animal species, except dairy ruminants, would not pose a risk for the consumer. However, in the absence of data on p-phenetidine residues in tissues and products of animal origin, no co nclusion on the safety for the co nsumer could be drawn. The co nclusions on co nsumer safety assume that the maximum total co ncentration of 50 mg EQ/kg feed is expressed as the sum of EQ, EQDM, EQI and DHEQ. Exposure of the unprotected user to p-phenetidine via inhalation should be minimised. No safety co ncerns for groundwater are expected. It is not possible to co nclude on the safety of EQ for the terrestrial compartment. A risk for the aquatic compartment cannot be excluded when ethoxyquin is used in terrestrial animals. Unacceptable risk is not expected for freshwater sediment-dwelling organisms. A risk of seco ndary poiso ning via the terrestrial food chain is not expected, wher eas a risk via the aquatic food chain cannot be excluded. No co ncerns for aquatic organisms are expected for ethoxyquin used in fish farmed in land-ba sed system, a risk cannot be excluded for marine sediment dwelling organisms when ethoxyquin is used in sea-cages. Ethoxyquin is co nsidered efficacious in the range 25–50 mg/kg complete feed.