經過評估，專家小組認為在擬議的使用條件下，該添加劑對目標物種、消費者和環境是安全的。評估中的添加劑被認為是非反芻動物物種氨基酸L-蛋氨酸的有效來源。為了使補充的L-蛋氨酸對反芻動物和非反芻動物同樣有效，需要防止其在瘤胃中降解。部分原文報道如下：

 

　　Following a request from the European Commission, the FEEDAP Panel was asked to deliver a scientific opinion on the safety and efficacy of l-methio nine ≥ 98.5% or ≥ 90% produced by the combined activities of Corynebacterium glutamicum KCCM 80245 and Escherichia coli KCCM 80246) as nutritio nal additive for all animal species. The two production strains are genetically modified. l-Methio nine is intended to be used in feed or water for drinking for all animal species. Neither viable cells nor recombinant DNA of the production strains were detected in the final products. The additive does not pose any safety co ncern associated with the genetic modification of the production strains. The use of both products of l-methio nine produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 in supplementing feed to compensate for l-methio nine deficiency in feedingstuffs is safe for the target species. The FEEDAP Panel has co ncerns a bout the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of both products of l-methio nine produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 in animal nutrition is co nsidered safe for the co nsumers and for the environment. The additive, in either product, is not an irritant to skin/eyes and not a dermal sensitiser and shows no toxicity by inhalation. Co nsidering the respiratory exposure to endotoxins, l-methio nine ≥ 90% is a risk for the user. Both products of the additive produced by C. glutamicum KCCM 80245 and E. coli KCCM 80246 are co nsidered as an efficacious source of the essential amino acid l-methio nine for non-ruminant animal species. For the supplemental l-methio nine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.