無極4平台_歐盟評估一種內切多聚半乳糖醛酸酶的

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無極4平台_歐盟評估一種內切多聚半乳糖醛酸酶的

    食品夥伴網訊  2022年4月28日,歐盟食品安全局就一種內切多聚半乳糖醛酸酶(endo-polygalacturonase)的安全性評價發布意見。

 
  據了解,這種食品酶是由轉基因硫球麴黴(Aspergillus luchuensis)菌株FLYSC生產的,旨在用於水果和蔬菜加工中,以生產果汁。
 
  經過評估,專家小組認為,在預期的使用條件下,對於對雪松、草花粉或玉米過敏的個體,不能排除飲食暴露引起過敏和誘發反應的風險。根據所提供的數據,小組得出結論,該食品酶在預期的使用條件下不會引起安全隱患。部分原文報道如下:
 
  The food enzyme endo-polygalacturo nase ((1→4)-α-d-galacturo nan glycanohydrolase; EC 2.3.1.15), is produced with the genetically modified Aspergillus luchuensis strain FLYSC by Advanced Enzyme Technologies Ltd. The genetic modifications do not give rise to safety concerns. The food enzyme is co nsidered free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in fruit and vegetable processing for juice production. ba sed on the maximum use level, dietary exposure to the food enzyme–total organic solids (TOS) was estimated to be up to 0.138 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 800 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 5,800. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and six matches were found. The Panel co nsidered that, under the intended co nditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded for individuals sensitised to cedar or grass pollen or maize. ba sed on the data provided, the Panel co ncluded that this food enzyme does not give rise to safety concerns, under the intended co nditions of use.